Eurohead Consortium Products

This page includs the Consortium Members' pubblications related to the genetic and neurobiological basis of the migraine pain, the aura, and the initiation of attacks.

The wolframin His611Arg polymorphism influences medication overuse headache.

Di Lorenzo C, Sances G, Di Lorenzo G, Rengo C, Ghiotto N, Guaschino E, Perrotta A, Santorelli FM, Grieco GS, Troisi A, Siracusano A, Pierelli F, Nappi G, Casali C.

Neurosci Lett 2007;424:179-84.

A role for brain cyclooxygenase-2 and prostaglandin-E2 in migraine: effects of nitroglycerin.

Tassorelli C, Greco R, Armentero MT, Blandini F, Sandrini G, Nappi G.

Int Rev Neurobiol 2007;82:373-82.

Early-onset progressive ataxia associated with the first CACNA1A mutation identified within the I-II loop.

Cricchi F, Di Lorenzo C, Grieco GS, Rengo C, Cardinale A, Racaniello M, Santorelli FM, Nappi G, Pierelli F, Casali C.

J Neurol Sci 2007;254:69-71.

Recurrent ATP1A2 mutations in Portuguese families with familial hemiplegic migraine.

Castro MJ, Stam AH, Lemos C, Barros J, Gouveia RG, Martins IP, Koenderink JB, Vanmolkot KR, Mendes AP, Frants RR, Ferrari MD, Sequeiros J, Pereira-Monteiro JM, van den Maagdenberg AM.

J Hum Genet. 2007 Oct 19; [Epub ahead of print]

Genetic models of migraine.

van de Ven RC, Kaja S, Plomp JJ, Frants RR, van den Maagdenberg AM, Ferrari MD.

Arch Neurol 2007;64:643-6.

The phe-124-Cys and A-161T variants of the human 5-HT1B receptor gene are not major determinants of the clinical response to sumatriptan.

Mehrotra S, Vanmolkot KR, Frants RR, van den Maagdenberg AM, Ferrari MD, MaassenVanDenBrink A.

Headache 2007;47:711-6.

Migraine: gene mutations and functional consequences.

van den Maagdenberg AM, Haan J, Terwindt GM, Ferrari MD.

Curr Opin Neurol 2007;20:299-305.

First case of compound heterozygosity in Na,K-ATPase gene ATP1A2 in familial hemiplegic migraine.

Vanmolkot KR, Stam AH, Raman A, Koenderink JB, de Vries B, van den Boogerd EH, van Vark J, van den Heuvel JJ, Bajaj N, Terwindt GM, Haan J, Frants RR, Ferrari MD, van den Maagdenberg AM.

Eur J Hum Genet 2007;15:884-8.

Severely impaired neuromuscular synaptic transmission causes muscle weakness in the Cacna1a-mutant mouse rolling Nagoya.

Kaja S, van de Ven RC, van Dijk JG, Verschuuren JJ, Arahata K, Frants RR, Ferrari MD, van den Maagdenberg AM, Plomp JJ.

Eur J Neurosci 2007;25:2009-20.

The novel p.L1649Q mutation in the SCN1A epilepsy gene is associated with familial hemiplegic migraine: genetic and functional studies. Mutation in brief #957. Online.

Vanmolkot KR, Babini E, de Vries B, Stam AH, Freilinger T, Terwindt GM, Norris L, Haan J, Frants RR, Ramadan NM, Ferrari MD, Pusch M, van den Maagdenberg AM, Dichgans M.

Hum Mutat 2007;28:522.

Redundancy of Cav2.1 channel accessory subunits in transmitter release at the mouse neuromuscular junction.

Kaja S, Todorov B, van de Ven RC, Ferrari MD, Frants RR, van den Maagdenberg AM, Plomp JJ.

Brain Res 2007;1143:92-101.

Treatment of hemiplegic migraine with triptans.

Artto V, Nissilä M, Wessman M, Palotie A, Färkkilä M, Kallela M.

Eur J Neurol 2007;14:1053-6.

No association of migraine to the GABA-A receptor complex on chromosome 15.

Oswell G, Kaunisto MA, Kallela M, Hämäläinen E, Anttila V, Kaprio J, Färkkilä M, Wessman M, Palotie A.

Am J Med Genet B Neuropsychiatr Genet. 2007 Jun 19; [Epub ahead of print]

Migraine: a complex genetic disorder.

Wessman M, Terwindt GM, Kaunisto MA, Palotie A, Ophoff RA.

Lancet Neurol 2007;6:521-32.

The vestibulo-collic reflex is abnormal in migraine.

Allena M, Magis D, De Pasqua V, Schoenen J.

Cephalalgia 2007;27:1150-5.

Interictal habituation deficit of the nociceptive blink reflex: an endophenotypic marker for presymptomatic migraine?

Di Clemente L, Coppola G, Magis D, Fumal A, De Pasqua V, Di Piero V, Schoenen J.

Brain 2007;130:765-70.

The genetic spectrum of a population-based sample of familial hemiplegic migraine.

Thomsen LL, Kirchmann M, Bjornsson A, Stefansson H, Jensen RM, Fasquel AC, Petursson H, Stefansson M, Frigge ML, Kong A, Gulcher J, Stefansson K, Olesen J.

Brain 2007;130:346-56.

Molecular nature of anomalous L-type calcium channels in mouse cerebellar granule cells.

Koschak A, Obermair GJ, Pivotto F, Sinnegger-Brauns MJ, Striessnig J, Pietrobon D.

J Neurosci 2007;27:3855-63.

Familial hemiplegic migraine.

Pietrobon D.

Neurotherapeutics 2007;4:274-84.

Association between migraine and the G1246A polymorphism in the hypocretin receptor 2 gene.

Schürks M, Limmroth V, Geissler I, Tessmann G, Savidou I, Engelbergs J, Kurth T, Diener HC, Rosskopf D.

Headache 2007;47:1195-9.

Migraine with isolated facial pain: a diagnostic challenge.

Obermann M, Mueller D, Yoon MS, Pageler L, Diener H, Katsarava Z.

Cephalalgia 2007;27:1278-82.

Validation of a german language questionnaire for screening for migraine, tension-type headache, and trigeminal autonomic cephalgias.

Fritsche G, Hueppe M, Kukava M, Dzagnidze A, Schuerks M, Yoon MS, Diener HC, Katsarava Z.

Headache 2007;47:546-51.

Cannabinoid (CB1) receptor activation inhibits trigeminovascular neurons.

Akerman S, Holland PR, Goadsby PJ.

J Pharmacol Exp Ther 2007;320:64-71.

Obesity, migraine, and chronic migraine: possible mechanisms of interaction.

Bigal ME, Lipton RB, Holland PR, Goadsby PJ.

Neurology 2007;68:1851-61.

Dopamine inhibits trigeminovascular transmission in the rat.

Bergerot A, Storer RJ, Goadsby PJ.

Ann Neurol 2007;61:251-62.

Increased urinary excretion of nitric oxide metabolites in longitudinally monitored migraine patients.

Rejdak K, Empl M, Giffin NJ, Afridi SK, Petzold A, Stelmasiak Z, Thompson EJ, Goadsby PJ, Kaube H, Giovannoni G.

Eur J Neurol 2006;13:1346-51

Intravital microscopy on a closed cranial window in mice: a model to study trigeminovascular mechanisms involved in migraine.

Gupta S, Akerman S, van den Maagdenberg AM, Saxena PR, Goadsby PJ, van den Brink AM.

Cephalalgia 2006;26:1294-303.

Practical management of medication-overuse headache.

Paemeleire K, Crevits L, Goadsby PJ, Kaube H.

Acta Neurol Belg 2006;106:43-51.

Functional neuroimaging of primary headache disorders.

Cohen AS, Goadsby PJ.

Expert Rev Neurother 2006;6:1159-71.

Bath-related headache: the first European case.

Rossi P, Nappi G.

Cephalalgia 2006;26:1485-6.

Headache attributed to infection: observations on the IHS classification (ICHD-II).

Marchioni E, Tavazzi E, Bono G, Minoli L, Bastianello S, Sinforiani E, Sances G, Tinelli C, Nappi G.

Cephalalgia 2006;26:1427-33.

Diaries and calendars for migraine. A review.

Nappi G, Jensen R, Nappi RE, Sances G, Torelli P, Olesen J.

Cephalalgia 2006;26:905-16.

Alternating hemiplegia of childhood: no mutations in the glutamate transporter EAAT1.

de Vries B, Haan J, Stam AH, Vanmolkot KR, Stroink H, Laan LA, Gill DS, Pascual J, Frants RR, van den Maagdenberg AM, Ferrari MD.

Neuropediatrics 2006;37:302-4.

Conditional inactivation of the Cacna1a gene in transgenic mice.

Todorov B, van de Ven RC, Kaja S, Broos LA, Verbeek SJ, Plomp JJ, Ferrari MD, Frants RR, van den Maagdenberg AM.

Genesis 2006;44:589-94.

Magnetic resonance angiography of the human middle meningeal artery: implications for migraine.

Schoonman GG, Bakker D, Schmitz N, van der Geest RJ, van der Grond J, Ferrari MD, van Buchem MA.

J Magn Reson Imaging 2006;24:918-21.

Genetic biomarkers for migraine.

De Vries B, Haan J, Frants RR, Van den Maagdenberg AM, Ferrari MD.

Headache 2006;46:1059-68.

Testing of variants of the MTHFR and ESR1 genes in 1798 Finnish individuals fails to confirm the association with migraine with aura.

Kaunisto MA, Kallela M, Hämäläinen E, Kilpikari R, Havanka H, Harno H, Nissilä M, Säkö E, Ilmavirta M, Liukkonen J, Teirmaa H, Törnwall O, Jussila M, Terwilliger J, Färkkilä M, Kaprio J, Palotie A, Wessman M.

Cephalalgia 2006;26:1462-72.

Comorbidity in Finnish migraine families.

Artto V, Wessman M, Nissilä M, Säkö E, Liukkonen J, Teirmaa H, Harno H, Havanka H, Ilmavirta M, Palotie A, Färkkilä M, Kallela M.

J Headache Pain 2006;7:324-30.

Trait components provide tools to dissect the genetic susceptibility of migraine.

Anttila V, Kallela M, Oswell G, Kaunisto MA, Nyholt DR, Hamalainen E, Havanka H, Ilmavirta M, Terwilliger J, Sobel E, Peltonen L, Kaprio J, Farkkila M, Wessman M, Palotie A.

Am J Hum Genet 2006;79:85-99.

Animal models of migraine: looking at the component parts of a complex disorder.

Bergerot A, Holland PR, Akerman S, Bartsch T, Ahn AH, MaassenVanDenBrink A, Reuter U, Tassorelli C , Schoenen J , Mitsikostas DD, van den Maagdenberg AM , Goadsby PJ.

Eur J Neurosci 2006;24:1517-34.

Medication overuse headache.

Fumal A, Magis D, Schoenen J

Rev Med Liege 2006;61:217-22.

Validation of the deCODE Migraine Questionnaire (DMQ3) for use in genetic studies.

Kirchmann M, Seven E, Björnsson A, Björnssdóttir G, Gulcher JR, Stefánsson K , Olesen J.

Eur J Neurol 2006;13:1239-44.

Vasoactive intestinal polypeptide evokes only a minimal headache in healthy volunteers.

Hansen JM, Sitarz J, Birk S, Rahmann AM, Oturai PS, Fahrenkrug J , Olesen J , Ashina M.

Cephalalgia 2006;26:992-1003.

Phosphodiesterase 3 and 5 and cyclic nucleotide-gated ion channel expression in rat trigeminovascular system.

Kruse LS, Sandholdt NT, Gammeltoft S , Olesen J , Kruuse C.

Neurosci Lett 2006;404:202-7.

Pain sensitivity in mice lacking the Ca(v)2.1alpha1 subunit of P/Q-type Ca2+ channels.

Luvisetto S, Marinelli S, Panasiti MS, D'Amato FR, Fletcher CF, Pavone F , Pietrobon D.

Neuroscience 2006;142:823-32.

A novel method of eliciting pain-related potentials by transcutaneous electrical stimulation.

Katsarava Z, Ayzenberg I, Sack F, Limmroth V , Diener HC , Kaube H.

Headache 2006;46:1511-7.

One-year prevalence and socio-cultural aspects of chronic headache in Turkish immigrants and German natives.

Kavuk I, Weimar C, Kim BT, Gueneyli G, Araz M, Klieser E, Limmroth V , Diener HC , Katsarava Z.

Cephalalgia 2006;26:1177-81.

Central sensitization of the trigeminal and somatic nociceptive systems in medication overuse headache mainly involves cerebral supraspinal structures.

Ayzenberg I, Obermann M, Nyhuis P, Gastpar M, Limmroth V , Diener HC , Kaube H, Katsarava Z.

Cephalalgia 2006;26:324-8.

A novel ATP1A2 mutation in a family with FHM type II.

Pierelli F, Grieco GS, Pauri F, Pirro C, Fiermonte G, Ambrosini A, Costa A, Buzzi MG, Valoppi M, Caltagirone C, Nappi G, Santorelli FM.

Cephalalgia 2006;26:324-8.

The CACNA1A and ATP1A2 genes are not involved in dominantly inherited migraine with aura.

Kirchmann M, Thomsen LL, Olesen J.

Am J Med Genet B Neuropsychiatr Genet. 2006 Feb 28; [Epub ahead of print]

Two de novo mutations in the Na,K-ATPase gene ATP1A2 associated with pure familial hemiplegic migraine.

Vanmolkot KR, Kors EE, Turk U, Turkdogan D, Keyser A, Broos LA, Kia SK, van den Heuvel JJ, Black DF, Haan J, Frants RR, Barone V, Ferrari MD, Casari G, Koenderink JB, van den Maagdenberg AM.

Eur J Hum Genet 2006 Mar 15; [Epub ahead of print]

Severe episodic neurological deficits and permanent mental retardation in a child with a novel FHM2 ATP1A2 mutation.

Vanmolkot KR, Stroink H, Koenderink JB, Kors EE, van den Heuvel JJ, van den Boogerd EH, Stam AH, Haan J, De Vries BB, Terwindt GM, Frants RR, Ferrari MD, van den Maagdenberg AM.

Ann Neurol 2006;59:310-4

Compensatory contribution of Cav2.3 channels to acetylcholine release at the neuromuscular junction of Tottering mice.

Kaja S, Van de Ven RC, Ferrari MD, Frants RR, Van den Maagdenberg AM, Plomp JJ.

J Neurophysiol 2005 Dec 28; [Epub ahead of print]

Gene dosage-dependent transmitter release changes at neuromuscular synapses of CACNA1A R192Q knockin mice are non-progressive and do not lead to morphological changes or muscle weakness.

Kaja S, van de Ven RC, Broos LA, Veldman H, van Dijk JG, Verschuuren JJ, Frants RR, Ferrari MD, van den Maagdenberg AM, Plomp JJ.

Neuroscience 2005;135:81-95

Mutation in the neuronal voltage-gated sodium channel SCN1A in familial hemiplegic migraine.

Dichgans M, Freilinger T, Eckstein G, Babini E, Lorenz-Depiereux B, Biskup S, Ferrari MD, Herzog J, van den Maagdenberg AM, Pusch M, Strom TM.

Lancet 2005;366:371-7

Migraine genetics: an update.

Haan J, Kors EE, Vanmolkot KR, van den Maagdenberg AM, Frants RR, Ferrari MD.

Curr Pain Headache Rep 2005;9:213-20

Chromosome 19p13 loci in Finnish migraine with aura families.

Kaunisto MA, Tikka PJ, Kallela M, Leal SM, Papp JC, Korhonen A, Hamalainen E, Harno H, Havanka H, Nissila M, Sako E, Ilmavirta M, Kaprio J, Farkkila M, Ophoff RA, Palotie A, Wessman M.

Am J Med Genet B Neuropsychiatr Genet 2005;132: 85-9.

Migraine: new molecular mechanisms.

Pietrobon D.

Neuroscientist 2005;11:373-86.

ATP1A2 mutations in 11 families with familial hemiplegic migraine.

Riant F, De Fusco M, Aridon P, Ducros A, Ploton C, Marchelli F, Maciazek J, Bousser MG, Casari G, Tournier-Lasserve E.

Hum Mutat 2005;26:281.

Familial basilar migraine associated with a new mutation in the ATP1A2 gene.

Ambrosini A, D'Onofrio M, Grieco GS, Di Mambro A, Montagna G, Fortini D, Nicoletti F, Nappi G, Sances G, Schoenen J, Buzzi MG, Santorelli FM, Pierelli F.

Neurology 2005;65:1826-8.

Nociceptive blink reflex and visual evoked potential habituations are correlated in migraine.

Di Clemente L, Coppola G, Magis D, Fumal A, De Pasqua V, Schoenen J.

Headache 2005;45:1388-93.

MR-spectroscopic imaging during visual stimulation in subgroups of migraine with aura.

Sandor PS, Dydak U, Schoenen J, Kollias SS, Hess K, Boesiger P, Agosti RM.

Cephalalgia 2005;25:507-18.

Prodromes in migraine Clinical and Neuropsychological Approach.

Sandrini G, Kropp P, Nappi G.

Funct Neurol 2005;20:177.

www.cefalea.it: the first five years.

Rossi P, Sances G, Nappi G.

J Headache Pain 2005;6:264-7.

Sensitivity and specificity of the new international diagnostic criteria for migraine with aura.

Eriksen MK, Thomsen LL, Olesen J.

J Neurol Neurosurg Psychiatry 2005;76:212-7.

Neurophysiological approach to central pain modulation in primary headaches.

Rossi P, Serrao M, Perrotta A, Pierelli F, Sandrini G, Nappi G.

J Headache Pain 2005;6:191-4.

Familial basilar migraine associated with a new mutation in the ATP1A2 gene.

Ambrosini A, D'Onofrio M, Grieco GS, Di Mambro A, Montagna G, Fortini D, Nicoletti F, Nappi G, Sances G, Schoenen J, Buzzi MG, Santorelli FM, Pierelli F.

Neurology 2005;65:1826-8.

Migraine with and without aura: electrophysiological and functional neuroimaging evidence.

Bramanti P, Grugno R, Vitetta A, Di Bella P, Muscara N, Nappi G.

Funct Neurol 2005;20:29-32.

Activation of the transcription factor NF-kappaB in the nucleus trigeminalis caudalis in an animal model of migraine.

Greco R, Tassorelli C, Cappelletti D, Sandrini G, Nappi G.

Neurotoxicology 2005;26:795-800.

Single-fiber EMG in familial hemiplegic migraine.

Terwindt GM, Kors EE, Vein AA, Ferrari MD, van Dijk JG.

Neurology 2004;63:1942-3.

Alternating hemiplegia of childhood: no mutations in the second familial hemiplegic migraine gene ATP1A2.

Kors EE, Vanmolkot KR, Haan J, Kheradmand Kia S, Stroink H, Laan LA, Gill DS, Pascual J, van den Maagdenberg AM, Frants RR, Ferrari MD.

Neuropediatrics 2004;35:293-6.

Childhood epilepsy, familial hemiplegic migraine, cerebellar ataxia, and a new CACNA1A mutation.

Kors EE, Melberg A, Vanmolkot KR, Kumlien E, Haan J, Raininko R, Flink R, Ginjaar HB, Frants RR, Ferrari MD, van den Maagdenberg AM.

Neurology 2004;63:1136-7.

Recent findings in headache genetics.

Kors EE, Vanmolkot KR, Haan J, Frants RR, van den Maagdenberg AM, Ferrari MD.

Curr Opin Neurol 2004;17:283-8

Toward a molecular genetic classification of familial hemiplegic migraine.

Haan J, Kors EE, van den Maagdenberg AM, Vanmolkot KR, Terwindt GM, Frants RR, Ferrari MD.

Curr Pain Headache Rep 2004;8:238-43.

Kinetic alterations due to a missense mutation in the Na,K-ATPase alpha2 subunit cause familial hemiplegic migraine type 2.

Segall L, Scanzano R, Kaunisto MA, Wessman M, Palotie A, Gargus JJ, Blostein R.

J Biol Chem 2004;279:43692-6.

A novel missense ATP1A2 mutation in a Finnish family with familial hemiplegic migraine type 2.

Kaunisto MA, Harno H, Vanmolkot KR, Gargus JJ, Sun G, Hamalainen E, Liukkonen E, Kallela M, van den Maagdenberg AM, Frants RR, Farkkila M, Palotie A, Wessman M.

Neurogenetics 2004;5:141-6.

Modal gating of human CaV2.1 (P/Q-type) calcium channels: I. The slow and the fast gating modes and their modulation by beta subunits.

Luvisetto S, Fellin T, Spagnolo M, Hivert B, Brust PF, Harpold MM, Stauderman KA, Williams ME, Pietrobon D.

J Gen Physiol 2004;124:445-61.

Sporadic hemiplegic migraine.

Thomsen LL, Olesen J.

Cephalalgia 2004;24:1016-23.

Clinical characteristics of 362 patients with familial migraine with aura.

Eriksen MK, Thomsen LL, Andersen I, Nazim F, Olesen J.

Cephalalgia 2004;24:564-75.

Characteristics of menstrual and nonmenstrual attacks in women with menstrually related migraine referred to headache centres.

Granella F, Sances G, Allais G, Nappi RE, Tirelli A, Benedetto C, Brundu B, Facchinetti F, Nappi G.

Cephalalgia 2004;24:707-16.

This page last modified: 30/10/2007