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KASGlostrup

Danish Headache Centre, Glostrup University Hospital & University of Copenhagen, Denmark

Prof. Olesen will coordinate the contribution from Glostrup Universiy Hospital (KASGlostrup). His expertise includes headache classification, (genetic) epidemiological and functional twin studies, such as cortical spreading depression and attack provocation. For the Consortium, he will perform clinical studies on migraine patients together with University of Duisburg-Essen (Uni Essen) and University of Liège (Ulg).

Summary of relevant expertise

  1. Neurophysiology of migraine provocation. Substances such as nitric oxide, more specifically its a pro-drug glyceryl trinitrate, histamine and calcitonin gene-related peptide can induce genuine migraine attacks. Nitric oxide inhibition is effective treatment of spontaneous attacks. Mechanisms of action of these drugs need to be elucidated. There are indications that the increase of cyclic GMP that occurs after nitric oxide (NO) administration is involves, since the phosphodiesterase 5-inhibitor sildenafil also very effectively induces attacks in migraine sufferers.
  2. Epidemiology and classification of migraine.Diagnosis in migraine is difficult, mainly because biochemical markers are lacking. Therefore, headache classification is important. Contribution to migraine (genetic) epidemiology by collecting large cohorts of twins, and collection of familial hemiplegic migraine (FHM) families.

Five recent publications: (From a total of >300 Peer-reviewed publications)

The CACNA1A and ATP1A2 genes are not involved in dominantly inherited migraine with aura.

Kirchmann M, Thomsen LL, Olesen J.

Am J Med Genet B Neuropsychiatr Genet. 2006 Feb 28; [Epub ahead of print]

Sensitivity and specificity of the new international diagnostic criteria for migraine with aura.

Eriksen MK, Thomsen LL, Olesen J.

J Neurol Neurosurg Psychiatry 2005;76:212-7.

Sporadic hemiplegic migraine.

Thomsen LL, Olesen J.

Cephalalgia 2004;24:1016-23.

New international classification of migraine with aura (ICHD-2) applied to 362 migraine patients.

Eriksen MK, Thomsen LL, Olesen J.

Eur J Neurol 2004;11:583-91.

Clinical characteristics of 362 patients with familial migraine with aura.

Eriksen MK, Thomsen LL, Andersen I, Nazim F, Olesen J.

Cephalalgia 2004;24:564-75.

This page last modified: 06/04/2006